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How often a particular steroid should be administered will depend on a few factors, with injection frequency being governed primarily by the half-life of each steroid, the sensitivity of a particular person's adrenal glands or the age of the patient. However, a patient will most likely require more frequent injections because the longer the steroid is administered, the more it can affect the heart, kidneys and liver. Although no one can be certain where the steroid will do its damage, these are some of the main reasons this procedure is not a good place to start: Cancer. The heart is composed of multiple capillaries containing multiple branches that are interconnected but separate so that a single heart attack can be triggered by a combination of several small heart attacks. These arteries are lined with cholesterol and some fatty deposits that form fat tissue. As it is difficult to inject steroid without a needle in the heart, the risk of cancer becomes a bigger factor. Heart failure. The cardiovascular system may be more affected in people with heart failure because the veins that supply blood to the body may not be capable of sending sufficient blood to the heart. As a result, large doses of steroid may be needed to achieve a desired effect. Herniorrhaphy. Another concern is that steroid injections could potentially trigger a serious condition called herniorrhaphy. Symptoms are generally the same as for heart failure, and include muscle aches, dizziness, shortness of breath and headaches. Tumors/Growths. If the steroid was injected into an area with abnormal blood clotting, such as in the brain or skull, a steroid injection could create a blood clot. Liver toxicity. For example, during a liver disease, the body releases substances called neurotransmitters into the blood. These substances are involved in communication between the brain and body, so it is important that the correct drugs can be given to those who are suffering from a common ailment. Fungal infection. Many types of fungi make their homes in the body, and once inside, many fungi attack the liver and cause cirrhosis and inflammation. This may mean that steroids are needed in larger doses to achieve desired effects (which may be in the range of multiple injections per month). Blood clots. If you have had surgery, it's easy to see that blood clots can get stuck between muscle tissues, causing a heart attack. Treatment An over-the-counter solution has been developed by the FDA for people who wish to avoid the risk of steroid injection: Aspirin. To find one, visit your local pharmacy, or go in for Related Article: